Label-free molecular interaction determinations with nanoscale interferometry.

  title={Label-free molecular interaction determinations with nanoscale interferometry.},
  author={Dmitry A. Markov and Kelly A Swinney and Darryl J. Bornhop},
  journal={Journal of the American Chemical Society},
  volume={126 50},
Quantification of protein-protein and ligand-substrate interactions is central to understanding basic cellular function and for evaluating therapeutics. To mimic biological conditions, such studies are best executed without modifying the proteins or ligands (i.e., label-free). While tools for label-free assays exist, they have limitations making them difficult to fully integrate into microfluidic devices. Furthermore, it has been problematic to reduce detection volumes for on-channel universal… CONTINUE READING
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