Label-free molecular interaction determinations with nanoscale interferometry.

@article{Markov2004LabelfreeMI,
  title={Label-free molecular interaction determinations with nanoscale interferometry.},
  author={Dmitry A. Markov and Kelly A Swinney and Darryl J. Bornhop},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 50},
  pages={16659-64}
}
Quantification of protein-protein and ligand-substrate interactions is central to understanding basic cellular function and for evaluating therapeutics. To mimic biological conditions, such studies are best executed without modifying the proteins or ligands (i.e., label-free). While tools for label-free assays exist, they have limitations making them difficult to fully integrate into microfluidic devices. Furthermore, it has been problematic to reduce detection volumes for on-channel universal… CONTINUE READING
Highly Cited
This paper has 42 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.
14 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…