Label-free liquid crystal biosensor based on specific oligonucleotide probes for heavy metal ions.

@article{Yang2013LabelfreeLC,
  title={Label-free liquid crystal biosensor based on specific oligonucleotide probes for heavy metal ions.},
  author={Shengyuan Yang and Chao Wu and Hui Tan and Yan Wu and Shuzhen Liao and Zhaoyang Wu and Guoli Shen and Ruqin Yu},
  journal={Analytical chemistry},
  year={2013},
  volume={85 1},
  pages={14-8}
}
In this study, to enhance the capability of metal ions disturbing the orientation of liquid crystals (LCs), we designed a new label-free LC biosensor for the highly selective and sensitive detection of heavy metal ions. This strategy makes use of the target-induced DNA conformational change to enhance the disruption of target molecules for the orientation of LC leading to an amplified optical signal. The Hg(2+) ion, which possesses a unique property to bind specifically to two DNA thymine (T… CONTINUE READING