Label-free imaging of Schwann cell myelination by third harmonic generation microscopy.

@article{Lim2014LabelfreeIO,
  title={Label-free imaging of Schwann cell myelination by third harmonic generation microscopy.},
  author={Hyungsik Lim and Denis Sharoukhov and Imran Kassim and Yanqing Zhang and James L. Salzer and Carmen V. Melendez-Vasquez},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 50},
  pages={18025-30}
}
Understanding the dynamic axon-glial cell interaction underlying myelination is hampered by the lack of suitable imaging techniques. Here we demonstrate third harmonic generation microscopy (THGM) for label-free imaging of myelinating Schwann cells in live culture and ex vivo and in vivo tissue. A 3D structure was acquired for a variety of compact and noncompact myelin domains, including juxtaparanodes, Schmidt-Lanterman incisures, and Cajal bands. Other subcellular features of Schwann cells… CONTINUE READING

6 Figures & Tables

Topics

Statistics

01020201620172018
Citations per Year

Citation Velocity: 5

Averaging 5 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.