Label-free electrochemical aptasensor for femtomolar detection of 17β-estradiol.

@article{Zhu2015LabelfreeEA,
  title={Label-free electrochemical aptasensor for femtomolar detection of 17β-estradiol.},
  author={Bicheng Zhu and Omar A. Alsager and Shalen Kumar and Justin M Hodgkiss and Jadranka Travas-Sejdic},
  journal={Biosensors & bioelectronics},
  year={2015},
  volume={70},
  pages={
          398-403
        }
}
  • Bicheng Zhu, Omar A. Alsager, +2 authors Jadranka Travas-Sejdic
  • Published in Biosensors & bioelectronics 2015
  • Chemistry, Medicine
  • We report an electrochemical aptasensor for the rapid, label-free detection of 17β-estradiol (E2) from femtomolar to micromolar levels. The sensor features an aptamer-functionalised nanoporous conducting polymer electrode whose surface potential is probed via electrochemical impedance spectroscopy. The unprecedented detection limit for E2 is explained via the redistribution of negative charges in the electrode double-layer region when the aptamer adopts a folded conformation around the small… CONTINUE READING

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