Label-free detection of ApoE4-mediated β-amyloid aggregation on single nanoparticle uncovering Alzheimer's disease.

@article{Kang2015LabelfreeDO,
  title={Label-free detection of ApoE4-mediated β-amyloid aggregation on single nanoparticle uncovering Alzheimer's disease.},
  author={Min Kyung Kang and Jeewon Lee and Anh Hai Nguyen and Sang Jun Sim},
  journal={Biosensors & bioelectronics},
  year={2015},
  volume={72},
  pages={197-204}
}
Beta amyloid (Aβ) deposition is a pathological milestone of Alzheimer's disease (AD). This is facilitated by an isoform of Apolipoprotein E4 (ApoE4), which is a dominant risk factor for AD. However, current in vitro Aβ aggregation assays were performed in extreme conditions not linked to physiological conditions, to understand the mechanism of Aβ induced neurotoxicity. Here, we present a simple method for the ApoE4-mediated Aβ aggregation at physiological conditions using single gold… CONTINUE READING
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