Label-free, microfluidic separation and enrichment of human breast cancer cells by adhesion difference.

@article{Kwon2007LabelfreeMS,
  title={Label-free, microfluidic separation and enrichment of human breast cancer cells by adhesion difference.},
  author={K. W. Kwon and Sung Sik Choi and Sang ho Lee and Byungkyu Kim and Se Na Lee and Min Cheol Park and Pilnam Kim and Se Yon Hwang and Kahp Y. Suh},
  journal={Lab on a chip},
  year={2007},
  volume={7 11},
  pages={1461-8}
}
A label-free microfluidic method for separation and enrichment of human breast cancer cells is presented using cell adhesion as a physical marker. To maximize the adhesion difference between normal epithelial and cancer cells, flat or nanostructured polymer surfaces (400 nm pillars, 400 nm perpendicular, or 400 nm parallel lines) were constructed on the bottom of polydimethylsiloxane (PDMS) microfluidic channels in a parallel fashion using a UV-assisted capillary moulding technique. The… CONTINUE READING

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