Label-Free Single-Molecule Imaging with Numerical-Aperture-Shaped Interferometric Scattering Microscopy

@inproceedings{Cole2017LabelFreeSI,
  title={Label-Free Single-Molecule Imaging with Numerical-Aperture-Shaped
Interferometric Scattering Microscopy},
  author={Daniel W Cole and Gavin Young and Alexander Weigel and Aleksandar Sebesta and Philipp Kukura},
  booktitle={ACS photonics},
  year={2017}
}
Our ability to optically interrogate nanoscopic objects is controlled by the difference between their extinction cross sections and the diffraction-limited area to which light can be confined in the far field. We show that a partially transmissive spatial mask placed near the back focal plane of a high numerical aperture microscope objective enhances the… CONTINUE READING