Label-Free Neurosurgical Pathology with Stimulated Raman Imaging.

  title={Label-Free Neurosurgical Pathology with Stimulated Raman Imaging.},
  author={Fa-Ke Lu and David Calligaris and Olutayo I. Olubiyi and Isaiah Norton and Wenlong Yang and Sandro S. Santagata and Xiaoliang Sunney Xie and Alexandra J. Golby and Nathalie Y. R. Agar},
  journal={Cancer research},
  volume={76 12},
The goal of brain tumor surgery is to maximize tumor removal without injuring critical brain structures. Achieving this goal is challenging as it can be difficult to distinguish tumor from nontumor tissue. While standard histopathology provides information that could assist tumor delineation, it cannot be performed iteratively during surgery as freezing, sectioning, and staining of the tissue require too much time. Stimulated Raman scattering (SRS) microscopy is a powerful label-free chemical… CONTINUE READING