Label‐free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time‐resolved G‐protein activity and distinct AngII and AngIIIIV responses

@article{Lavenus2018LabelfreeCS,
  title={Label‐free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time‐resolved G‐protein activity and distinct AngII and AngIIIIV responses},
  author={S. Lavenus and {\'E}lie Simard and {\'E}. Besserer-Offroy and U. Froehlich and R. Leduc and M. Grandbois},
  journal={Pharmacological Research},
  year={2018},
  volume={136},
  pages={108–120}
}
  • S. Lavenus, Élie Simard, +3 authors M. Grandbois
  • Published 2018
  • Chemistry, Medicine, Biology
  • Pharmacological Research
  • ABSTRACT Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein‐coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases. Its functions are mediated through G protein dependent and independent signaling pathways. AT1R has several endogenous peptidic agonists, all derived from angiotensinogen, as well as several synthetic ligands known to elicit biased signaling responses. Here, surface plasmon resonance (SPR) was used as a cell… CONTINUE READING
    1 Citations
    Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain.
    • 2
    • PDF

    References

    SHOWING 1-10 OF 78 REFERENCES
    Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity
    • 19
    • PDF
    Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II.
    • 455
    • PDF
    Mechanoactivation of the angiotensin II type 1 receptor induces β‐arrestin‐biased signaling through Gαi coupling
    • 15
    Activation of extracellular signal-activated kinase by angiotensin II-induced Gq-independent epidermal growth factor receptor transactivation.
    • 47
    • PDF
    Deciphering biased-agonism complexity reveals a new active AT1 receptor entity.
    • 140
    Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms
    • 2
    • PDF
    Label-Free Monitoring of μ-Opioid Receptor–Mediated Signaling
    • 8
    • PDF