LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport.

  title={LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport.},
  author={Jose L. Puglisi and Donald M. Bers},
  journal={American journal of physiology. Cell physiology},
  volume={281 6},
An interactive computer program, LabHEART, was developed to simulate the action potential (AP), ionic currents, and Ca handling mechanisms in a rabbit ventricular myocyte. User-oriented, its design allows switching between voltage and current clamp and easy on-line manipulation of key parameters to change the original formulation. The model reproduces normal rabbit ventricular myocyte currents, Ca transients, and APs. We also changed parameters to simulate data from heart failure (HF) myocytes… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 82 extracted citations


Publications referenced by this paper.
Showing 1-10 of 37 references

A mathematical model describes the SR load-dependence of Ca dynamics in cardiac myocytes (Abstract)

  • TR Shannon, DM Bers
  • Biophys J 80:
  • 2001
1 Excerpt

Mechanisms of altered excitation-contraction coupling in canine C2059 LABHEART: AN INTERACTIVE MYOCYTE COMPUTER MODEL AJP-Cell Physiol

  • RL Winslow, J Rice, S Jafri, E Marban, B. O’Rourke
  • Circ Res
  • 2001
1 Excerpt

Increased Na/Ca exchange and reduced IK1 facilitate triggered action potentials in a rabbit model of heart failure (Abstract)

  • JL Puglisi, SM Pogwizd, W Yuan, DM. Bers
  • Biophys J 78:
  • 2000
1 Excerpt

Similar Papers

Loading similar papers…