• Corpus ID: 67711782

Lab-in-a-cell : Using Individual Cells as Experimentation Platforms

@inproceedings{Andersson2006LabinacellU,
  title={Lab-in-a-cell : Using Individual Cells as Experimentation Platforms},
  author={Helene Andersson and Albert van den Berg},
  year={2006}
}
There are many efforts today trying to mimic the pr operties of single cells in order to design chips that are a s efficient as cells. However, cells are nature’s nanotechnology engineer i g at the scale of atoms and molecules. Therefore, it might be better to envision a microchip that utilizes a single cell as an experim ntation platform. A novel so-called Lab-in-a-Cell (LIC) concept is desc ribed, where advantage is taken of micro/nanotechnological tools to enable precise control of the… 

Figures from this paper

From lab-on-a-chip to lab-in-a-cell

A novel, so-called Lab-in-a-Cell (LIC) concept is described, where advantage is taken of micro/nanotechnological tools to enable precise control of the biochemical cellular environment and possibility to analyze the composition of single cells.

References

SHOWING 1-10 OF 25 REFERENCES

Microfluidic devices for cellomics: a review

A Multi-purpose Micro System for Electrophysiological Analyses of Single Cells

The cellular analysis system was demonstrated by performing electrical impedance spectroscopy on chromaffin cells, air, and phosphate buffered solution (PBS) over a range from 40.0Hz to 1.0MHz.

An integrated nanoliter DNA analysis device.

A device was developed that uses microfabricated fluidic channels, heaters, temperature sensors, and fluorescence detectors to analyze nanoliter-size DNA samples to facilitate the use of DNA analysis in applications such as rapid medical diagnostics and point-of-use agricultural testing.

Chip based biosensor for functional analysis of single ion channels

A novel, silicon chip-based assay to probe the function of channel proteins, and the application of this technique in parallelized, highly sensitive biosensing devices for large-scale functional screening feasible.

Micro total analysis systems. 2. Analytical standard operations and applications.

This second part of the review of microfluidic system preparation will cover a number of standard operations as well as some biological applications of micro total analysis systems.

Single‐cell analysis using capillary electrophoresis: Influence of surface support properties on cell injection into the capillary

Analysis of the data obtained showed that PHEMA‐ and PVA‐coated glass slides were the most suitable cell supports for cell injection into the capillary.

Nanotechnology: convergence with modern biology and medicine.

  • M. Roco
  • Biology
    Current opinion in biotechnology
  • 2003

Apoptotic cell death dynamics of HL60 cells studied using a microfluidic cell trap device.

The design, fabrication and first results of a microfluidic cell trap device for analysis of apoptosis, a first step towards an integrated apoptosis chip for high-throughput drug screening on a single cellular level are presented.

Realization of hollow SiO2 micronozzles for electrical measurements on living cells

We present a microfluidic device for the immobilization and electrical measurements, such as patch-clamp or impedance measurements, on individual living cells. Micron-sized hollow SiO2 nozzles are

Three-dimensional micro flow manifolds for miniaturized chemical analysis systems

A three-dimensional (3D) stack concept for the assembly of photolithographically fabricated microfluidic components is presented and discussed. The system uses silicon-based micropumps and simple