LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq.

Abstract

Both canonical and alternative splicing of RNAs are governed by intronic sequence elements and produce transient lariat structures fastened by branch points within introns. To map precisely the location of branch points on a genomic scale, we developed LaSSO (Lariat Sequence Site Origin), a data-driven algorithm which utilizes RNA-seq data. Using fission… (More)
DOI: 10.1101/gr.166819.113

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