La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA.

@article{Ray2002LaAI,
  title={La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA.},
  author={Partho Sarothi Ray and Saumitra Das},
  journal={Nucleic acids research},
  year={2002},
  volume={30 20},
  pages={4500-8}
}
Translation initiation in Coxsackievirus B3 (CVB3) occurs via ribosome binding to an internal ribosome entry site (IRES) located in the 5'-untranslated region (UTR) of the viral RNA. This unique mechanism of translation initiation requires various trans-acting factors from the host. We show that human La autoantigen (La) binds to the CVB3 5'-UTR and also demonstrate the dose-dependent effect of exogenously added La protein in stimulating CVB3 IRES-mediated translation. The requirement of La for… CONTINUE READING

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