La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys

  title={La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys},
  author={Richard S. Bennett and Christina M. Cress and Jerrold M Ward and Cai Yen Firestone and Brian R. Murphy and Stephen S. Whitehead},
  journal={Virology Journal},
  pages={25 - 25}
La Crosse virus (LACV), family Bunyaviridae, was first identified as a human pathogen in 1960 after its isolation from a 4 year-old girl with fatal encephalitis in La Crosse, Wisconsin. LACV is a major cause of pediatric encephalitis in North America and infects up to 300,000 persons each year of which 70–130 result in severe disease of the central nervous system (CNS). As an initial step in the establishment of useful animal models to support vaccine development, we examined LACV infectivity… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 17 extracted citations


Publications referenced by this paper.
Showing 1-10 of 43 references

Treatment of severe La Crosse encephalitis with intravenous ribavirin following diagnosis by brain

  • JE McJunkin, R Khan, +4 authors TF Tsai
  • biopsy. Pediatrics
  • 1997
Highly Influential
5 Excerpts

Animal models of highly pathogenic RNA viral infections: Hemorrhagic fever viruses

  • M. R. Gowen BB Holbrook
  • Antiviral Research
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…