LYVE-1-positive macrophages are present in normal murine eyes.

  title={LYVE-1-positive macrophages are present in normal murine eyes.},
  author={Heping Xu and Mei Chen and Delyth M. Reid and John V. Forrester},
  journal={Investigative ophthalmology & visual science},
  volume={48 5},
PURPOSE A functioning lymphatic system is necessary not only to permit the organism to mount a rapid and effective immune response but, even more so, to maintain tissue fluid homeostasis. However, no clear evidence of lymphatic vessels draining intraocular and orbital tissues--retina, choroid, sclera, and extraocular muscles--exists. METHODS Ocular tissue flatmounts from normal or enhanced green fluorescence protein (EGFP) chimeric mice were immunostained for lymphatic endothelium hyaluronan… CONTINUE READING


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