LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals.

@article{Thirkettle2009LYRICAEG1IT,
  title={LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals.},
  author={Hayley J Thirkettle and Joanne Girling and Anne Y Warren and Ian G Mills and Kanagasabai Sahadevan and Hing Leung and Freddie Hamdy and Hayley C. Whitaker and David E. Neal},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 9},
  pages={3003-13}
}
PURPOSE LYRIC/AEG-1 has been reported to influence breast cancer survival and metastases, and its altered expression has been found in a number of cancers. The cellular function of LYRIC/AEG-1 has previously been related to its subcellular distribution in cell lines. LYRIC/AEG-1 contains three uncharacterized nuclear localization signals (NLS), which may regulate its distribution and, ultimately, function in cells. EXPERIMENTAL DESIGN Immunohistochemistry of a human prostate tissue microarray… CONTINUE READING
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