LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.

@article{Gao2011LYPAB,
  title={LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.},
  author={Jian-jun Gao and Xia Xue and Zu-hua Gao and Shu-xiang Cui and Yan-na Cheng and Wen-fang Xu and Wei Tang and Xianjun Qu},
  journal={Microvascular research},
  year={2011},
  volume={82 2},
  pages={122-30}
}
Our previous study revealed that LYP, a bestatin dimethylaminoethyl ester, inhibited the growth of human ovarian carcinoma ES-2 xenografts in mice and suppressed aminopeptidase N (APN/CD13) activity more potently than bestatin. In this study, we examined the inhibitory effect of LYP on migration and formation of capillary tube of human umbilical vascular endothelial cells (HUVECs) in vitro and anti-angiogenesis in ES-2 xenografts in mice. LYP did not possess cytotoxicity to HUVEC proliferation… CONTINUE READING
3 Citations
35 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 35 references

The synthesis and activity evaluation of a bestatin derivative ( LYP ) as an aminopeptidase N inhibitor

  • Y. P. Luan, X. J. Wang, H. W. Zhu, X. J. Qu, H. Fang, W. F. Xu
  • Lett . Drug Des . Discov .
  • 2009
Highly Influential
5 Excerpts

The synthesis and activity evaluation of a bestatin derivative (LYP) as an aminopeptidase

  • Y. P. Luan, X. J. Wang, H. W. Zhu, X. J. Qu, H. Fang, W. F. Xu
  • N inhibitor. Lett. Drug Des. Discov
  • 2009
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…