LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia

@article{ONeill2000LY377770AN,
  title={LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia},
  author={M. O'Neill and L. Bogaert and C. Hicks and A. Bond and D. Lodge},
  journal={Neuropharmacology},
  year={2000},
  volume={39},
  pages={1575-1588}
}
We have evaluated the neuroprotective effects of the decahydroisoquinoline LY377770, a novel iGlu5 kainate receptor antagonist, in two models of cerebral ischaemia. Global ischaemia, induced in gerbils by bilateral carotid artery occlusion (BCAO) for 5 min, produced a large increase in locomotor activity at 96 hr post-occlusion and a severe loss of CA1 cells in the hippocampus histologically at 120 hr post-occlusion. LY377770 (80 mg/kg i.p. 30 min before or 30 min after BCAO followed by 40 mg… Expand
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References

SHOWING 1-10 OF 78 REFERENCES
Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil
Neuroprotective Effect of the AMPA Receptor Antagonist LY-293558 in Focal Cerebral Ischemia in the Cat
A dose-response study of neuroprotection using the AMPA antagonist NBQX in rat focal cerebral ischemia.
Treatment with an AMPA Antagonist 12 Hours following Severe Normothermic Forebrain Ischemia Prevents CA1 Neuronal Injury
  • H. Li, A. Buchan
  • Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1993
...
1
2
3
4
5
...