LY294002 induces p53-dependent apoptosis of SGC7901 gastric cancer cells

  title={LY294002 induces p53-dependent apoptosis of SGC7901 gastric cancer cells},
  author={Chun-gen Xing and Bao-song Zhu and Hui-hui Liu and Fang Lin and Hui-hua Yao and Zhong-qin Liang and Zheng-Hong Qin},
  journal={Acta Pharmacologica Sinica},
AbstractAim:To study the effects of LY294002, an inhibitor of class I phosphatidylinositol 3-kinase (PI3K), on proliferation and apoptosis of SGC7901 gastric cancer cells.Methods:The MTT assay was used to determine the cytotoxic effects of LY294002. Cell cycle distribution was analyzed using flow cytometry and apoptosis was assessed using flow cytometry analysis after staining DNA with propidium iodide. Mitochondrial membrane potential was measured using the fluorescent probe JC-1. Expression… CONTINUE READING


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