LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake

@article{Wong1993LY248686AN,
  title={LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake},
  author={D. Wong and F. Bymaster and Douglas A. Mayle and L. R. Reid and J. Krushinski and D. Robertson},
  journal={Neuropsychopharmacology},
  year={1993},
  volume={8},
  pages={23-33}
}
LY248686 is an inhibitor of serotonin (5-hydroxytryptamine; 5-HT) and norepinephrine (NE) uptake in synaptosomal preparations of hypothalamus and cerebral cortex, and 5-HT uptake in human blood platelets, with inhibitor constants near nanomolar concentrations. Upon administration to rats 1 hour before sacrifice, LY248686 caused dose-dependent and parallel decreases of 5-HT and NE uptake in hypothalamus homogenates ex vivo. LY248686 is a positive enantiomer and was slightly more potent than its… Expand
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References

SHOWING 1-10 OF 58 REFERENCES
A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.
Inhibition of serotonin reuptake.
Characterization of [3H]Paroxetine Binding in Rat Brain
A new selective inhibitor for uptake of serotonin into synaptosomes of rat brain: 3-(p-trifluoromethylphenoxy). N-methyl-3-phenylpropylamine.
Effect of drugs on the uptake and metabolism of H3-norepinephrine.
Sertraline: a new antidepressant.
The comparison of fluoxetine and nisoxetine with tricyclic antidepressants in blocking the neurotoxicity of p-chloroamphetamine and 6-hydroxydopamine in the rat brain.
  • D. Wong, F. Bymaster
  • Medicine
  • Research communications in chemical pathology and pharmacology
  • 1976
...
1
2
3
4
5
...