LXR Deficiency Confers Increased Protection against Visceral Leishmania Infection in Mice

@inproceedings{Bruhn2010LXRDC,
  title={LXR Deficiency Confers Increased Protection against Visceral Leishmania Infection in Mice},
  author={Kevin W. Bruhn and Chaitra Marathe and Ana Cl{\'a}udia Maretti-Mira and Hong Thi Khanh Nguyen and Jacquelyn Haskell and Thu Anh Tran and Veena Vanchinathan and Upasna Gaur and Mary E Wilson and Peter Tontonoz and Noah Craft},
  booktitle={PLoS neglected tropical diseases},
  year={2010}
}
BACKGROUND The liver X receptors (LXRs) are a family of nuclear receptor transcription factors that are activated by oxysterols and have defined roles in both lipid metabolism and cholesterol regulation. LXRs also affect antimicrobial responses and have anti-inflammatory effects in macrophages. As mice lacking LXRs are more susceptible to infection by intracellular bacteria Listeria monocytogenes and Mycobacterium tuberculosis, we hypothesized that LXR might also influence macrophage responses… CONTINUE READING

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