LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.

@article{Patel2011LXRIR,
  title={LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.},
  author={Rucha Patel and Monika Patel and Ricky Tsai and Vicky Lin and Angie L. Bookout and Yuan Zhang and Lilia Magomedova and Tingting Li and Jessica F Chan and Conrad Budd and David J Mangelsdorf and Carolyn L Cummins},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 1},
  pages={431-41}
}
Although widely prescribed for their potent antiinflammatory actions, glucocorticoid drugs (e.g., dexamethasone) cause undesirable side effects that are features of the metabolic syndrome, including hyperglycemia, fatty liver, insulin resistance, and type II diabetes. Liver x receptors (LXRs) are nuclear receptors that respond to cholesterol metabolites and regulate the expression of a subset of glucocorticoid target genes. Here, we show LXRβ is required to mediate many of the negative side… CONTINUE READING