LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation.

@article{Gewirtz1999LXA4A1,
  title={LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation.},
  author={Andrew T. Gewirtz and Valery V Fokin and Nicos A Petasis and Charles N Serhan and James L. Madara},
  journal={The American journal of physiology},
  year={1999},
  volume={276 4 Pt 1},
  pages={C988-94}
}
The eicosanoid lipoxin A4 (LXA4) is biosynthesized in vivo by cells present at inflammatory sites and appears to be an endogenous anti-inflammatory mediator. Further, in the presence of aspirin, the 15-epimer of LXA4 (15-epi-LXA4) is biosynthesized and may mediate some of aspirin's desirable bioactions. LXA4, 15-epi-LXA4, and their stable analogs inhibit inflammation in established animal models, indicating that these compounds may be useful for treating inflammatory disease states. To… CONTINUE READING
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