LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB

@article{Noad2017LUBACsynthesizedLU,
  title={LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB},
  author={Jessica Noad and Alexander von der Malsburg and Claudio Pathe and Martin A. Michel and David Komander and Felix Randow},
  journal={Nature Microbiology},
  year={2017},
  volume={2}
}
Cell-autonomous immunity relies on the ubiquitin coat surrounding cytosol-invading bacteria functioning as an ‘eat-me’ signal for xenophagy. The origin, composition and precise mode of action of the ubiquitin coat remain incompletely understood. Here, by studying Salmonella Typhimurium, we show that the E3 ligase LUBAC generates linear (M1-linked) polyubiquitin patches in the ubiquitin coat, which serve as antibacterial and pro-inflammatory signalling platforms. LUBAC is recruited via its… CONTINUE READING
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