LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.

@article{Tokunaga2012LUBACAN,
  title={LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.},
  author={Fuminori Tokunaga and Kazuhiro Iwai},
  journal={Microbes and infection},
  year={2012},
  volume={14 7-8},
  pages={563-72}
}
LUBAC (linear ubiquitin chain assembly complex) is a ubiquitin ligase complex composed of SHARPIN, HOIL-IL and HOIP that generates linear polyubiquitin chains and regulates the NF-κB pathway, which is pivotal in inflammatory and immune responses. Recent findings on the regulation of NF-κB by LUBAC and the diseases associated with this process are the focus of this review.