LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite

@article{Toni1999LTPPF,
  title={LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite},
  author={Nicolas Toni and P A Buchs and Irina Nikonenko and Claude Bron and Dominique Muller},
  journal={Nature},
  year={1999},
  volume={402},
  pages={421-425}
}
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory. Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines. LTP induction resulted in a sequence of morphological changes consisting of a transient… CONTINUE READING
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