LTP of spinal Aβ and C‐fibre evoked responses after electrical sciatic nerve stimulation

  title={LTP of spinal A$\beta$ and C‐fibre evoked responses after electrical sciatic nerve stimulation},
  author={Frode Svendsen and Arne Tj{\o}lsen and Kjell J{\o}rgen Hole},
PLASTICITY in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extracellular recordings of firing responses after single pulse stimuli were made. The high-frequency conditioning stimulus increased the Aβ and C-fibre-mediated firing responses to… 

AMPA and NMDA receptor‐dependent spinal LTP after nociceptive tetanic stimulation

  • Frode SvendsenArne TjølsenK. Hole
  • Biology
  • 1998
It is shown that identical stimulation induced LTP only of the C-fibre evoked response after blockade of muscular contractions during the tetanus, indicating that both AMPA and NMDA receptor stimulation are involved in the induction of LTP.



Long-term potentiation in an isolated peripheral nerve-spinal cord preparation.

The capacity of the isolated neonatal rat spinal cord to sustain a long-lasting increase in a nociceptive-related slow ventral root potential (sVRP) recorded from a lumbar root after a tetanic train of stimuli to the peripheral cutaneous saphenous nerve is investigated.

Long-term potentiation and depression in the ventral horn of rat spinal cord in vitro.

The principal conclusion of the work is that LTP and LTD can be elicited in the ventral horn of the rat spinal cord.

Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord

  • C. WoolfA. King
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1990
The demonstration of the capacity of a relatively brief afferent barrage of chemosensitive nociceptors to produce an increase in the spatial extent of the cutaneous receptive fields of dorsal horn neurons, amplify their responsiveness, and reduce their thresholds has implications both for the pathogenesis of postinjury pain hypersensitivity phenomena and for receptive field plasticity in the somatosensory system.

A comparative study of the changes in receptive-field properties of multireceptive and nocireceptive rat dorsal horn neurons following noxious mechanical stimulation.

The results obtained in the halothane-anesthetized and decerebrate-spinal animals were very similar to those seen in the barbiturate-ansthetized experiments, with the exception that in the decerebrates, the RFs of the class 2 cells were initially larger and showed only small increases.

Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey

  • Pm DoughertyW. Willis
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1992
The results show that the background discharge rate and the responses of STT cells to mechanical stimulation increase following intradermal CAP, and it is proposed that an increase in the responses to EAAs contributes to the hyperalgesia produced by this noxious chemical stimulus.

Evidence for a central component of post-injury pain hypersensitivity

An animal model is developed where changes occur in the threshold and responsiveness of the flexor reflex following peripheral injury that are analogous to the sensory changes found in man, and shows that it in part arises from changes in the activity of the spinal cord.