# LTP of spinal Aβ and C‐fibre evoked responses after electrical sciatic nerve stimulation

@article{Svendsen1997LTPOS,
title={LTP of spinal A$\beta$ and C‐fibre evoked responses after electrical sciatic nerve stimulation},
author={Frode Svendsen and Arne Tj{\o}lsen and Kjell J{\o}rgen Hole},
journal={NeuroReport},
year={1997},
volume={8},
pages={3427–3430}
}
• Published 10 November 1997
• Biology
• NeuroReport
PLASTICITY in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extracellular recordings of firing responses after single pulse stimuli were made. The high-frequency conditioning stimulus increased the Aβ and C-fibre-mediated firing responses to…
• Frode SvendsenArne Tjølsen
• Biology
Neuroreport
• 1998
It is shown that identical stimulation induced LTP only of the C-fibre evoked response after blockade of muscular contractions during the tetanus, indicating that both AMPA and NMDA receptor stimulation are involved in the induction of LTP.

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