LTP of spinal Aβ and C‐fibre evoked responses after electrical sciatic nerve stimulation

@article{Svendsen1997LTPOS,
  title={LTP of spinal A$\beta$ and C‐fibre evoked responses after electrical sciatic nerve stimulation},
  author={Frode Svendsen and Arne Tj{\o}lsen and Kjell J{\o}rgen Hole},
  journal={NeuroReport},
  year={1997},
  volume={8},
  pages={3427–3430}
}
PLASTICITY in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extracellular recordings of firing responses after single pulse stimuli were made. The high-frequency conditioning stimulus increased the Aβ and C-fibre-mediated firing responses to… 
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105 Citations
Highly Influential Citations
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105 Citations

Natural noxious stimulation can induce long-term increase of spinal nociceptive responses

Long term potentiation of single WDR neurons in spinalized rats

AMPA and NMDA receptor‐dependent spinal LTP after nociceptive tetanic stimulation

  • Frode SvendsenArne TjølsenK. Hole
  • Biology
    Neuroreport
  • 1998
It is shown that identical stimulation induced LTP only of the C-fibre evoked response after blockade of muscular contractions during the tetanus, indicating that both AMPA and NMDA receptor stimulation are involved in the induction of LTP.

Recording of long-term potentiation in single dorsal horn neurons in vivo in the rat.

Different increase in C-fibre evoked responses after nociceptive conditioning stimulation in sham-operated and neuropathic rats

Increased ability to induce long-term potentiation of spinal dorsal horn neurones in monoarthritic rats

Spinal substance P release in vivo during the induction of long-term potentiation in dorsal horn neurons

Induction of long-term potentiation of single wide dynamic range neurones in the dorsal horn is inhibited by descending pathways

Long-term potentiation in single wide dynamic range neurons induced by noxious stimulation in intact and spinalized rats.

Spinal cord stimulation inhibits long-term potentiation of spinal wide dynamic range neurons

...

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