LTP-like synaptic efficacy changes following electroconvulsive stimulation.

  title={LTP-like synaptic efficacy changes following electroconvulsive stimulation.},
  author={Caroline A. Stewart and Kathryn Jeffery and Ian C. Reid},
  volume={5 9},
Synaptic plasticity is thought to represent a mechanism for memory formation. Memory disturbances commonly follow electroconvulsive therapy (ECT) for depression. Accordingly, we examined the development and duration of the effects of electroconvulsive stimulation (ECS) on hippocampal synaptic plasticity in rats. Daily recording of field potentials during 10 spaced ECS revealed an increase in the dentate gyrus evoked response, reaching a maximum after the fifth seizure. In a second experiment… CONTINUE READING
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