LTP and adaptation to inactivity: Overlapping mechanisms and implications for metaplasticity

@article{Thiagarajan2007LTPAA,
  title={LTP and adaptation to inactivity: Overlapping mechanisms and implications for metaplasticity},
  author={Tara C Thiagarajan and Maria Lindskog and Antonio Malgaroli and Richard W. Tsien},
  journal={Neuropharmacology},
  year={2007},
  volume={52},
  pages={156-175}
}
LTP and other rapidly induced forms of synaptic modification tune individual synaptic weights, whereas slower forms of plasticity such as adaptation to inactivity are thought to keep neurons within their firing limits and preserve their capability for information processing. Here we describe progress in understanding the relationship between LTP and adaptation to inactivity. A prevailing view is that adaptation to inactivity is purely postsynaptic, scales synaptic strength uniformly across all… Expand
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