LTP and LTD An Embarrassment of Riches

@article{Malenka2004LTPAL,
  title={LTP and LTD An Embarrassment of Riches},
  author={Robert C Malenka and Mark F. Bear},
  journal={Neuron},
  year={2004},
  volume={44},
  pages={5-21}
}
LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission, are widespread phenomena expressed at possibly every excitatory synapse in the mammalian brain. It is now clear that "LTP" and "LTD" are not unitary phenomena. Their mechanisms vary depending on the synapses and circuits in which they operate. Here we review those forms of LTP and LTD for which mechanisms have been most firmly established. Examples are provided that show how these mechanisms can… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 184 references

The synaptic vesicle cycle.

Annual review of neuroscience • 2004
View 4 Excerpts
Highly Influenced

nation regulates PSD-95 degradation and AMPA receptor

L. J. Faleiro, S. Jones, J. A. Kauer
2004
View 19 Excerpts
Highly Influenced

Heterosynaptic LTD of hip- Emptage

V. Chevaleyre, P. E. Castillo
cycling on PSD-95. Cell 108, • 2003
View 5 Excerpts
Highly Influenced

Regulation of AMPA receptors in vitro

R. L. Huganir
Neurosci . Lett . Trends Neurosci . • 2002
View 20 Excerpts
Highly Influenced

Can molecules explain longStaubli

J. R. Sanes, J. W. Lichtman
U., and Lynch, G • 1999
View 4 Excerpts
Highly Influenced

Role of AMPA receptor cycling long-term potentiation

R. C. Malenka, R. A. Nicoll
Neuron 36, 121–137. • 1999
View 11 Excerpts
Highly Influenced

Long-term potentiation and memory.

Physiological reviews • 2004
View 6 Excerpts
Highly Influenced

In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2003
View 4 Excerpts
Highly Influenced

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