LTP and LTD An Embarrassment of Riches

  title={LTP and LTD An Embarrassment of Riches},
  author={Robert C. Malenka and Mark F. Bear},

Synaptic plasticity in the subiculum

Dissecting the Components of Long-Term Potentiation

Some recent advances made possible by the development of new imaging tools have demonstrated that LTP is compound in nature and consists of both presynaptic and postsynaptic components.

Long-Term Depression: Cerebellum

LTP of GABAergic synapses in the ventral tegmental area and beyond

The recent study suggests that in vivo morphine initiates a long‐lasting alteration of GABAergic synapses in the ventral tegmental area (VTA) by blocking the mechanisms required for LTP of GABAergy synapses, which is put into the context of other examples of synaptic plasticity at GABAergicsynapses.

Long-Term Potentiation and Depression as Putative Mechanisms for Memory Formation

This chapter attempts an overview of the mechanisms underlying induction and maintenance of long-lasting activity-dependent synaptic modifications as at least one of the key mechanisms by which experiences modify neural circuit behavior.

Modulators of synaptic plasticity in the hippocampus

It is shown that supplementing aged mice with a precursor for GSH formation reverses the mechanisms underlying hippocampal LTP from L-type calcium channel dependence back to NMDA receptor-dependence, suggesting an important role for GSI as a modulator of synaptic plasticity in aging.



Synaptic plasticity: LTP and LTD

Long-term potentiation and memory.

  • T. Teyler
  • Biology
    International journal of neurology
  • 1987
A hypothesis will be examined that long-term potentiation in hippocampus and neocortex may subserve information storage in the central nervous system.

Synaptic plasticity in the mesolimbic dopamine system.

  • M. ThomasR. Malenka
  • Biology, Psychology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2003
The studies suggest that in vivo drugs of abuse such as cocaine cause long-lasting changes at excitatory synapses in the NAc and VTA owing to activation of the mechanisms that underlie LTP and LTD in these structures.

Postsynaptic induction and presynaptic expression of hippocampal long-term depression.

The induction of LTD in hippocampal CA1 pyramidal neurons in neonatal rats is shown to depend on postsynaptic calcium ion entry through L-type voltage-gated calcium channels paired with the activation of metabotropic glutamate receptors, suggesting that LTD is likely to require the production of a retrograde messenger.

Contrasting properties of two forms of long-term potentiation in the hippocampus

The two forms of LTP are compared and it is argued that the balance of evidence favours a postsynaptic locus for NMDA-receptor-dependent LTP.

A synaptic model of memory: long-term potentiation in the hippocampus

The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.

Synaptic plasticity

Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation

Using receptor antagonists, as well as receptor knockout mice, it is found that presynaptic kainate receptors facilitate the induction of mossy fiber long-term potentiation (LTP), although they are not required for this form of LTP.

AMPA receptor trafficking and synaptic plasticity.

The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.