LTP Promotes a Selective Long-Term Stabilization and Clustering of Dendritic Spines

@article{Roo2008LTPPA,
  title={LTP Promotes a Selective Long-Term Stabilization and Clustering of Dendritic Spines},
  author={Mathias de Roo and Paul Klauser and Dominique Muller},
  journal={PLoS Biology},
  year={2008},
  volume={6},
  pages={723 - 725}
}
Dendritic spines are the main postsynaptic site of excitatory contacts between neurons in the central nervous system. On cortical neurons, spines undergo a continuous turnover regulated by development and sensory activity. However, the functional implications of this synaptic remodeling for network properties remain currently unknown. Using repetitive confocal imaging on hippocampal organotypic cultures, we find that learning-related patterns of activity that induce long-term potentiation act… CONTINUE READING