LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.

@article{Xu2014LSECtinEO,
  title={LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.},
  author={Feng Xu and Jing Liu and Di Liu and Biao Liu and Min Wang and Zhiyuan Hu and Xuemei Du and Li Tang and Fuchu He},
  journal={Cancer research},
  year={2014},
  volume={74 13},
  pages={3418-28}
}
Therapeutic antibodies that target T-cell co-inhibitory molecules display potent antitumor effects in multiple types of cancer. LSECtin is a cell surface lectin of the DC-SIGN family expressed in dendritic cells that inhibits T-cell responses. LSECtin limits T-cell activity in infectious disease, but it has not been studied in cancer. Here we report the finding that LSECtin is expressed commonly in melanomas where it blunts tumor-specific T-cell responses. When expressed in B16 melanoma cells… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
21 Citations
42 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Tumor - in fi ltratingNYESO1speci fi cCD 8 þ T cells are negatively regulated by LAG3 andPD1 in humanovarian cancer

  • J Matsuzaki, S Gnjatic, P Mhawech-Fauceglia, A Miller, T Tsuji
  • ProcNatl Acad Sci U S A
  • 2010

Similar Papers

Loading similar papers…