LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer

  title={LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer},
  author={Jian-qing Ding and Z-M Zhang and Y Xia and G-Q Liao and Yihui Pan and Shi-min Liu and Yang Zhang and Z-S Yan},
  booktitle={British Journal of Cancer},
Background:Emerging evidence has demonstrated that lysine-specific demethylase 1 (LSD1) has an important role in many pathological processes of cancer cells, such as carcinogenesis, proliferation and metastasis. In this study, we characterised the role and molecular mechanisms of LSD1 in proliferation and metastasis of colon cancer.Methods:We evaluated the correlation of LSD1, CDH-1 and CDH-2 with invasiveness of colon cancer cells, and investigated the roles of LSD1 in proliferation, invasion… CONTINUE READING


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