LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

@article{Metzger2005LSD1DR,
  title={LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription},
  author={Eric Metzger and Melanie Wissmann and Na Yin and Judith M. M{\"u}ller and Robert Schneider and Antoine Hfm Peters and Thomas G{\"u}nther and Reinhard Buettner and Roland Sch{\"u}le},
  journal={Nature},
  year={2005},
  volume={437},
  pages={436-439}
}
Gene regulation in eukaryotes requires the coordinate interaction of chromatin-modulating proteins with specific transcription factors such as the androgen receptor. Gene activation and repression is specifically regulated by histone methylation status at distinct lysine residues. Here we show that lysine-specific demethylase 1 (LSD1; also known as BHC110) co-localizes with the androgen receptor in normal human prostate and prostate tumour. LSD1 interacts with androgen receptor in vitro and in… 

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The Jumonji C (JMJC) domain-containing protein JMJD2C is identified as the first histone tridemethylase regulating androgen receptor function and suggests that specific gene regulation requires the assembly and coordinate action of demethylases with distinct substrate specificities.

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ERRα induces H3K9 demethylation by LSD1 to promote cell invasion

It is shown that the estrogen-related receptor α (ERRα) induces LSD1 to erase repressive marks in vitro, identifying a regulatory network involving a direct switch in the biochemical activities of a histone demethylase, leading to increased cell invasion.

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Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4

Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation. As a component of co-repressor complexes, LSD1 contributes
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