LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

  title={LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription},
  author={Eric Metzger and Melanie Wissmann and Na Yin and Judith M. M{\"u}ller and Robert Schneider and Antoine Hfm Peters and Thomas G{\"u}nther and Reinhard Buettner and Roland Sch{\"u}le},
Gene regulation in eukaryotes requires the coordinate interaction of chromatin-modulating proteins with specific transcription factors such as the androgen receptor. Gene activation and repression is specifically regulated by histone methylation status at distinct lysine residues. Here we show that lysine-specific demethylase 1 (LSD1; also known as BHC110) co-localizes with the androgen receptor in normal human prostate and prostate tumour. LSD1 interacts with androgen receptor in vitro and in… 

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