LSD1 demethylates histone and non-histone proteins.

  title={LSD1 demethylates histone and non-histone proteins.},
  author={Thomas B. Nicholson and Taiping Chen},
  volume={4 3},
One of the key breakthroughs in the epigenetics/chromatin field in the last several years was the identification of enzymes capable of removing the methyl group from methylated lysines in histone proteins. Lysine-specific demethylase 1 (LSD1) was the first such enzyme identified, which has been shown to demethylate histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9). LSD1 is essential for mammalian development and likely involved in many biological processes. Recent studies show that LSD1… CONTINUE READING

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