LSD modulates music-induced imagery via changes in parahippocampal connectivity

@article{Kaelen2016LSDMM,
  title={LSD modulates music-induced imagery via changes in parahippocampal connectivity},
  author={Mendel Kaelen and Leor Roseman and Joshua Kahan and Andre Santos-Ribeiro and Csaba Orban and Romy Lorenz and Frederick Streeter Barrett and Mark Bolstridge and Tim M. Williams and Luke T J Williams and Matthew B. Wall and Amanda Feilding and Suresh D. Muthukumaraswamy and David J. Nutt and Robin Lester Carhart-Harris},
  journal={European Neuropsychopharmacology},
  year={2016},
  volume={26},
  pages={1099-1109}
}

Figures and Tables from this paper

Effect of LSD and music on the time-varying brain dynamics
Psychedelics are getting closer to being widely used in clinical treatment. Music is known as a key element of psychedelic-assisted therapy due to its psychological effects, specifically on the
Effects of LSD on music-evoked brain activity
TLDR
Results showed pronounced cortical and subcortical changes in music-evoked brain activity under LSD, and most notable changes in brain activity and connectivity were associated with the component timbral complexity, representing the complexity of the music’s spectral distribution.
Increased low-frequency brain responses to music after psilocybin therapy for depression
Psychedelic-assisted psychotherapy with psilocybin is an emerging therapy with great promise for depression, and modern psychedelic therapy (PT) methods incorporate music as a key element. Music is
Psychedelic resting-state neuroimaging: a review and perspective on balancing replication and novel analyses
TLDR
The review of the existing literature suggests that the psychedelic resting-state brain imaging field is at a crossroads at which it must also consider the critical importance of consistency and replicability to effectively converge on stable representations of the neural effects of psychedelics.
Modern Clinical Research on LSD
  • M. Liechti
  • Psychology, Medicine
    Neuropsychopharmacology
  • 2017
TLDR
All modern clinical studies using the classic hallucinogen lysergic acid diethylamide in healthy subjects or patients in the last 25 years are reviewed herein and should contribute to further investigations of the therapeutic potential of LSD in psychiatry.
“Telling me not to worry…” Hyperscanning and Neural Dynamics of Emotion Processing During Guided Imagery and Music
TLDR
Investigating the moment-to-moment interaction in music therapy showed how asymmetry peaks align with the situated cognition of Traveler and Guide along the emotional contour of the music, representing the highs and lows during the therapy process.
Alterations of consciousness and mystical-type experiences after acute LSD in humans
TLDR
Mystical-type experiences were infrequent after LSD, possibly because of the set and setting used in the present study, and ego dissolution may reflect plasma levels of LSD, whereas more robustly induced effects of LSD may not result in such associations.
Decreased Directed Functional Connectivity in the Psychedelic State
TLDR
Changes in functional connectivity following the controlled administration of LSD, psilocybin and low-dose ketamine as well as, for comparison, the (non-psychedelic) anticonvulsant drug tiagabine are described.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 84 REFERENCES
LSD enhances the emotional response to music
TLDR
These findings reinforce the long-held assumption that psychedelics enhance music-evoked emotion, and provide tentative and indirect support for the notion that this effect can be harnessed in the context of psychedelic-assisted psychotherapy.
Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations
TLDR
These results provide systematic evidence for the direct association of a specific spatiotemporal neuronal mechanism with spiritual experiences and enhanced insight into life and existence and may constitute a pathway for modulating mental health.
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
TLDR
Psilocybin caused a significant decrease in the positive coupling between the mPFC and PCC, which strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition.
Broadband Cortical Desynchronization Underlies the Human Psychedelic State
TLDR
The findings suggest that the subjective effects of psychedelics result from a desynchronization of ongoing oscillatory rhythms in the cortex, likely triggered by 5-HT2A receptor-mediated excitation of deep pyramidal cells.
Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin.
TLDR
Evidence that psilocybin enhances autobiographical recollection implies that it may be useful in psychotherapy either as a tool to facilitate the recall of salient memories or to reverse negative cognitive biases.
Enhanced repertoire of brain dynamical states during the psychedelic experience
TLDR
The present results provide a comprehensive account of the effects of psilocybin on dynamical behavior in the human brain at a macroscopic level and may have implications for the understanding of the unconstrained, hyper‐associative quality of consciousness in the psychedelic state.
Emotional responses to unpleasant music correlates with damage to the parahippocampal cortex.
TLDR
In this study, pleasant and unpleasant music was presented to 17 patients with variable excisions of the medial temporal lobe, as well as to 19 matched controls; the same patients judged consonant music to be pleasant, and were able to judge music as happy or sad.
Cortical stimulation study of the role of rhinal cortex in déjà vu and reminiscence of memories
TLDR
This study strongly suggests that experiential symptoms are largely dependent upon functional modification of the physiology of the rhinal cortices.
Topographic pharmaco-EEG mapping of the effects of the South American psychoactive beverage ayahuasca in healthy volunteers.
TLDR
The q-EEG profile supports the role of 5-HT2 and dopamine D2-receptor agonism in mediating the effects of ayahuasca on the central nervous system, and shows a time pattern which closely paralleled that of previously reported subjective effects.
A functional MRI study of happy and sad affective states induced by classical music
TLDR
The findings suggest that an emotion processing network in response to music integrates the ventral and dorsal striatum, areas involved in reward experience and movement; the anterior cingulate, which is important for targeting attention; and medial temporal areas, traditionally found in the appraisal and processing of emotions.
...
1
2
3
4
5
...