LSD and Genetic Damage

@article{Dishotsky1971LSDAG,
  title={LSD and Genetic Damage},
  author={Norman I. Dishotsky and William D. Loughman and Robert E. Mogar and Wendell R. Lipscomb},
  journal={Science},
  year={1971},
  volume={172},
  pages={431 - 440}
}
Of nine studies in vitro, six have indicated some degree of induced chromosomal breakage after exposure to LSD; three failed to confirm these results. The damage, when found, was generally of the chromatid type, arising during or after DNA synthesis. This damage, with one exception, was the result of concentrations of drug and durations of exposure which could not be achieved in humans with reasonable dosages. There did not appear to be a dose-response relation. The magnitude of damage, when… 

Effects of LSD on human chromosomes.

Chemical mutagenesis and drugs of abuse in man - a current view of the problem.

  • A. Falek
  • Medicine
    International pharmacopsychiatry
  • 1972
From 1958 through 1962 evidence accumulated that the drug thalidomide, when taken by pregnant women between the 34th and 50th day after the first day of the last menstrual period, resulted in ear and

Lack of chromosomal damaging effects by moderate doses of LSD in vivo

Four schizophrenic children were treated with weekly doses of LSD‐25 as part of a study of the effects of this drug on beharior and there was no increased chromosomal damage on exposure to LSD either at the time of treatment or up to one year later.

Embryotoxicity of Drugs in Man

Until more effective systems for prior testing and later surveillance for possible teratogenic effects of chemicals are in operation, however, frequent scrutiny in the form of surveys and reviews may serve to maintain a degree of alertness, if not provide the needed safeguard.

LSD…an in vivo retrospective chromosome study

A retrospective in vivo study was carried out using as experimental subjects psychiatric patients who were treated under clinical conditions with known amounts of pure d-LSD 25 and the results of cytogenetic studies performed on 32 experimental subjects and on 32 controls were reported.

Induced chromosomal aberrations in man.

  • A. Bloom
  • Biology, Medicine
    Advances in human genetics
  • 1972
Recent epidemiological evidence, from mutagen-exposed human populations, and recent experiments on viral-induced transformation of chromosomally abnormal cells suggest an association between chromosome aberrations and oncogenesis.
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