LSD and Genetic Damage

  title={LSD and Genetic Damage},
  author={Norman I. Dishotsky and William D. Loughman and Robert E. Mogar and Wendell R. Lipscomb},
  pages={431 - 440}
Of nine studies in vitro, six have indicated some degree of induced chromosomal breakage after exposure to LSD; three failed to confirm these results. The damage, when found, was generally of the chromatid type, arising during or after DNA synthesis. This damage, with one exception, was the result of concentrations of drug and durations of exposure which could not be achieved in humans with reasonable dosages. There did not appear to be a dose-response relation. The magnitude of damage, when… 

Effects of LSD on human chromosomes.

Chemical mutagenesis and drugs of abuse in man - a current view of the problem.

  • A. Falek
  • Medicine
    International pharmacopsychiatry
  • 1972
From 1958 through 1962 evidence accumulated that the drug thalidomide, when taken by pregnant women between the 34th and 50th day after the first day of the last menstrual period, resulted in ear and

Lack of chromosomal damaging effects by moderate doses of LSD in vivo

Four schizophrenic children were treated with weekly doses of LSD‐25 as part of a study of the effects of this drug on beharior and there was no increased chromosomal damage on exposure to LSD either at the time of treatment or up to one year later.

Embryotoxicity of Drugs in Man

Until more effective systems for prior testing and later surveillance for possible teratogenic effects of chemicals are in operation, however, frequent scrutiny in the form of surveys and reviews may serve to maintain a degree of alertness, if not provide the needed safeguard.

LSD…an in vivo retrospective chromosome study

A retrospective in vivo study was carried out using as experimental subjects psychiatric patients who were treated under clinical conditions with known amounts of pure d-LSD 25 and the results of cytogenetic studies performed on 32 experimental subjects and on 32 controls were reported.

Induced chromosomal aberrations in man.

  • A. Bloom
  • Biology, Medicine
    Advances in human genetics
  • 1972
Recent epidemiological evidence, from mutagen-exposed human populations, and recent experiments on viral-induced transformation of chromosomally abnormal cells suggest an association between chromosome aberrations and oncogenesis.



Cytogenetic effects of LSD 25 therapy in man.

It is felt that continued experimental therapy with lysergic acid diethylamide is not strongly contraindicated, and results can not be construed to minimize the possible cytogenetic hazards suggested by other studies concerned primarily with drug abuse.

In vitro Interaction of LSD with Purified Calf Thymus DNA

THE observation of broken chromosomes in test animals and humans treated with the hallucinogen lysergic acid diethylamide (LSD) has been well documented1–8. Although there has been some speculation

Lethal Mutation Rate in Drosophila exposed to LSD-25 by Injection and Ingestion

Reports have recently appeared which indicate that while LSD-25 is not apparently mutagenic when injected directly in D. melanogaster males in amounts as great as 500 µg/ml, it is capable of producing X-linked recessive lethal mutations when doses some twenty times larger are used.

Persistent chromosome aberrations in irradiated human subjects.

Chromosomes of a number of men exposed to whole-body mixed gamma and fission neutron irradiation, as well as those of five unirradiated control individuals, were examined, finding variations in number and form of their chromosomes.

Chromosome aberrations in leukocytes exposed in vitro to diagnostic levels of x-rays.

Since each leukocyte is subject to a different exposure depending upon its location in the body during the exposure, radiation dosimetry for human in vivo studies is particularly inaccurate at low exposures.

The Chemical Production of Mutations

In one case, when DNA is treated inside the cell, its reactions would not be expected to be always identical with those observed in vitro; in one case they have, indeed, been found to be different.

In Vivo Effects of Diagnostic X-Irradiation on Human Chromosomes

The present study was designed to evaluate the possible chromosomal effects of different diagnostic x-ray procedures at .

Lysergide and chromosome abnormalities.

The marked reduction in tolerance was found principally in patients in whom the original investigations had shown obviously diabetic glucose and glucose-cortisone tolerance, but it was not found only in the patients who had the longest duration of treatment.

Aneuploidy and age in a population survey.

The chromosome constitution of a statistically determined probability sample of the population of the metropolitan area of Buffalo, New York is investigated to yield information on the distribution of deviations from the diploid number in an unselected population and provide data for comparison with other groups of subjects.