LSD‐induced entropic brain activity predicts subsequent personality change

@article{Lebedev2016LSDinducedEB,
  title={LSD‐induced entropic brain activity predicts subsequent personality change},
  author={Alexander V. Lebedev and Mendel Kaelen and Martin L{\"o}vd{\'e}n and Johan Nilsson and Amanda Feilding and David J. Nutt and Robin Lester Carhart-Harris},
  journal={Human Brain Mapping},
  year={2016},
  volume={37}
}
Personality is known to be relatively stable throughout adulthood. Nevertheless, it has been shown that major life events with high personal significance, including experiences engendered by psychedelic drugs, can have an enduring impact on some core facets of personality. In the present, balanced‐order, placebo‐controlled study, we investigated biological predictors of post‐lysergic acid diethylamide (LSD) changes in personality. Nineteen healthy adults underwent resting state functional MRI… 

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References

SHOWING 1-10 OF 90 REFERENCES

Enhanced repertoire of brain dynamical states during the psychedelic experience

The present results provide a comprehensive account of the effects of psilocybin on dynamical behavior in the human brain at a macroscopic level and may have implications for the understanding of the unconstrained, hyper‐associative quality of consciousness in the psychedelic state.

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

The findings suggest that the subjective effects of psychedelics result from a desynchronization of ongoing oscillatory rhythms in the cortex, likely triggered by 5-HT2A receptor-mediated excitation of deep pyramidal cells.

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin

Psilocybin caused a significant decrease in the positive coupling between the mPFC and PCC, which strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition.

Neural correlates of the LSD experience revealed by multimodal neuroimaging

Three complementary neuroimaging techniques, implemented during resting state conditions, revealed marked changes in brain activity after LSD that correlated strongly with its characteristic psychological effects, contributing important new insights into the characteristic hallucinatory and consciousness-altering properties of psychedelics.

Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations

These results provide systematic evidence for the direct association of a specific spatiotemporal neuronal mechanism with spiritual experiences and enhanced insight into life and existence and may constitute a pathway for modulating mental health.

Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis.

It is suggested that this orthogonality is compromised in early psychosis, explaining similarities between its phenomenology and that of the psychedelic state and supporting the utility of psilocybin as a model of early psychosis.

The paradoxical psychological effects of lysergic acid diethylamide (LSD)

The present findings reinforce the view that psychedelics elicit psychosis-like symptoms acutely yet improve psychological wellbeing in the mid to long term, and are proposed that acute alterations in mood are secondary to a more fundamental modulation in the quality of cognition.

Finding the self by losing the self: Neural correlates of ego‐dissolution under psilocybin

The results implicate MTL‐cortical decoupling, decreased salience network integrity, and reduced inter‐hemispheric communication in psilocybin‐induced ego disturbance and suggest that the maintenance of “self”or “ego,” as a perceptual phenomenon, may rest on the normal functioning of these systems.

The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers

Changes in resting-state functional connectivity between a standard template of different independent components analysis (ICA)-derived resting state networks under the influence of two different psychoactive drugs, the stimulant/psychedelic hybrid, MDMA, and the classic psychedelic, psilocybin are measured.
...