LRRK2 mutations in Parkinson's disease: Confirmation of a gender effect in the Italian population

@inproceedings{Cilia2014LRRK2MI,
  title={LRRK2 mutations in Parkinson's disease: Confirmation of a gender effect in the Italian population},
  author={Roberto Cilia and Chiara Siri and Damiana Rusconi and Roberta Allegra and Andrea Ghiglietti and Giorgio Sacilotto and Michela Zini and Anna Lena Zecchinelli and Rosanna Asselta and Stefano Duga and Anna Maria Paganoni and Gianni Pezzoli and Manuela Seia and Stefano Goldwurm},
  booktitle={Parkinsonism & related disorders},
  year={2014}
}
BACKGROUND The relative risk of developing idiopathic PD is 1.5 times greater in men than in women, but an increased female prevalence in LRRK2-carriers has been described in the Ashkenazi Jewish population. We report an update about the frequency of major LRRK2 mutations in a large series of consecutive patients with Parkinson's disease (PD), including extensive characterization of clinical features. In particular, we investigated gender-related differences in motor and non-motor symptoms in… CONTINUE READING

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