LRRK2 mutations are not common in Alzheimer's disease.

  title={LRRK2 mutations are not common in Alzheimer's disease.},
  author={Mathias Toft and Sigrid Botne Sando and Stacey Melquist and Owen A. Ross and Linda Rosemary White and Jan O Aasly and Matthew J Farrer},
  journal={Mechanisms of ageing and development},
  volume={126 11},
The development of common age-related neurodegenerative disorders as Parkinson's disease and Alzheimer's disease (AD) are influenced by genetic factors. Recently, pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified in familial Parkinsonism. Individuals in some of these families developed symptoms of dementia with Lewy-bodies and AD. The LRRK2 gene is also located within a locus on chromosome 12 reported in late-onset AD, and is therefore a good candidate… CONTINUE READING
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