LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

@inproceedings{Hinkle2012LRRK2KM,
  title={LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors},
  author={Kelly M. Hinkle and Mei Yue and Bahareh Behrouz and Justus C. D{\"a}chsel and Sarah J. Lincoln and Erin E. Bowles and Joel E. Beevers and Brittany Nicole Dugger and Beate Winner and Iryna Prots and Caroline B Kent and Kenya Nishioka and Wen-lang Lin and Dennis W. Dickson and Christopher J Janus and Matthew J Farrer and Heather L. Melrose},
  booktitle={Molecular Neurodegeneration},
  year={2012}
}
Mutations in the LRRK2 gene are the most common cause of genetic Parkinson’s disease. Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in regulating neuronal polarity, neurotransmission, membrane and cytoskeletal dynamics and protein degradation.We created mice lacking exon 41 that encodes the activation hinge of the kinase domain of LRRK2. We have performed a comprehensive analysis of… CONTINUE READING
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Lachenmayer ML: Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications

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