LRRK2 gene in Parkinson disease: mutation analysis and case control association study.

@article{PaisnRuiz2005LRRK2GI,
  title={LRRK2 gene in Parkinson disease: mutation analysis and case control association study.},
  author={Coro Pais{\'a}n-Ruiz and Anthony E Lang and T Kawarai and Christine Sato and Shabnam Salehi-Rad and G K Fisman and Thamer Al-Khairallah and Peter St George-Hyslop and Andrew A Singleton and Ekaterina A. Rogaeva},
  journal={Neurology},
  year={2005},
  volume={65 5},
  pages={696-700}
}
BACKGROUND In addition to the four well-confirmed genes linked to early-onset Parkinson disease (PD) (SNCA, PARKIN, DJ-1, and PINK1), mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have recently been identified in families with autosomal dominant late-onset PD. OBJECTIVE To perform mutation analysis of LRRK2 in probands of families showing dominant inheritance of PD and to conduct a case control association study to test the hypothesis that common coding variations might be… CONTINUE READING

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