LRRK2 Phosphorylation: Behind the Scenes.

  title={LRRK2 Phosphorylation: Behind the Scenes.},
  author={Tina De Wit and Veerle Baekelandt and Evy Lobbestael},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are known today as the most common genetic cause of Parkinson's disease (PD). LRRK2 is a large protein that is hypothesized to regulate other proteins as a scaffold in downstream signaling pathways. This is supported by the multiple domain composition of LRRK2 with several protein-protein… CONTINUE READING