LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.

@article{Zabetian2006LRRK2GI,
  title={LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.},
  author={Cyrus P Zabetian and Carolyn M. Hutter and Dora Yearout and Alexis N Lopez and S A Factor and A. Elizabeth Griffith and Berta C. Leis and Thomas Bird and John G. Nutt and Donald S. Higgins and John W. Roberts and Denise M Kay and Karen L. Edwards and A. Samii and Haydeh Payami},
  journal={American journal of human genetics},
  year={2006},
  volume={79 4},
  pages={
          752-8
        }
}
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is the most common genetic determinant of Parkinson disease (PD) identified to date. It accounts for 1%-7% of PD in patients of European origin and 20%-40% in Ashkenazi Jews and North African Arabs with PD. Previous studies concluded that patients from these populations all shared a common Middle Eastern founder who lived in the 13th century. We tested this hypothesis by genotyping 25 microsatellite and single-nucleotide-polymorphism… CONTINUE READING
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