LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics

@inproceedings{Yao2017LRP6PI,
  title={LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics},
  author={Qian Yao and Yu An and Wei Ming Xia Hou and Ya-Nan Cao and Meng-Fei Yao and Ning-ning Ma and Lin Hou and Hong Zhang and Hai-jing Liu and Bo Zhang},
  booktitle={Oncotarget},
  year={2017}
}
Low density lipoprotein (LDL) receptor-related protein-6 (LRP6) is an important co-receptor of Wnt pathway, which plays a predominant role in development and progression of colorectal cancer. Recently, dysregulation of LRP6 has proved to be involved in the progression of cancers, but its biological role and clinical significance in colorectal cancer remain unclear. In present study, we revealed that phosphorylation of LRP6 was aberrantly upregulated in colorectal carcinoma correlating with TNM… CONTINUE READING
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