LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation.

@article{Chen2014LRP6DT,
  title={LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation.},
  author={Jinxiao Chen and H. Yan and Dan-ni Ren and Y. Yin and Z. Li and Qingqing He and Da Wo and M. Ho and Y. Chen and Z. Liu and J. Yang and S. Liu and W. Zhu},
  journal={Cellular signalling},
  year={2014},
  volume={26 5},
  pages={
          1068-74
        }
}
  • Jinxiao Chen, H. Yan, +10 authors W. Zhu
  • Published 2014
  • Biology, Medicine
  • Cellular signalling
  • Canonical Wnt/β-catenin signaling pathway plays important roles in multiple aspects of cellular responses in development and diseases. It is currently thought that Wnt receptor Frizzled (Frz) exists separately to Wnt coreceptors LRP5 and LRP6 (LRP5/6), and that Wnt-Frz-LRP5/6 triple complex formation bridged by Wnt ligand is needed for canonical pathway activation. We recently showed that Frz and LRP5/6 interact with each other in the absence of Wnt ligand binding and this interaction maintains… CONTINUE READING
    26 Citations
    Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway
    • 9
    • PDF
    Receptor heterodimerization as a novel mechanism for the regulation of Wnt/&bgr;-catenin signaling
    • 14
    • PDF
    Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase
    • 5
    • PDF
    Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.
    • 28
    • PDF
    Frizzleds and WNT/β-catenin signaling--The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics.
    • G. Schulte
    • Biology, Medicine
    • European journal of pharmacology
    • 2015
    • 32
    Assembly and architecture of the Wnt/β‐catenin signalosome at the membrane
    • 21
    • Highly Influenced
    Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1.
    • 28
    • Highly Influenced
    Wnt3a suppresses Wnt/β-catenin signaling and cancer cell proliferation following serum deprivation.
    • 5

    References

    SHOWING 1-10 OF 48 REFERENCES
    A mechanism for Wnt coreceptor activation.
    • 507
    • PDF
    A Novel Mechanism for Wnt Activation of Canonical Signaling through the LRP6 Receptor
    • 147
    • PDF
    LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • 981