LRP5 knockdown: effect on prostate cancer invasion growth and skeletal metastasis in vitro and in vivo

@inproceedings{Rabbani2013LRP5KE,
  title={LRP5 knockdown: effect on prostate cancer invasion growth and skeletal metastasis in vitro and in vivo},
  author={Shafaat A. Rabbani and Ani Arakelian and Riaz Farookhi},
  booktitle={Cancer medicine},
  year={2013}
}
Prostate cancer (PCa) is a common hormone-dependent malignancy associated with the development of skeletal metastases. This is due to the increased expression of a number of growth factors, cytokines, and proteases which collectively drive the metastatic cascade in general and increased propensity to develop skeletal metastasis in particular. While a number of signaling pathways have been implicated in PCa progression, the highly complex wnt/β-catenin pathway is unique due to its ability to… CONTINUE READING
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