LRP5 and LRP6 in development and disease.

  title={LRP5 and LRP6 in development and disease.},
  author={Danese M. Joiner and Jiyuan Ke and Zhendong Zhong and Hongjiao Xu and Bart O. Williams},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={24 1},
Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are highly homologous proteins with key functions in canonical Wnt signaling. Alterations in the genes encoding these receptors or their interacting proteins are linked to human diseases, and as such they have been a major focus of drug development efforts to treat several human conditions including osteoporosis, cancer, and metabolic disease. Here, we discuss the links between alterations in LRP5/6 and disease, proteins that interact… CONTINUE READING
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