LRP4 Serves as a Coreceptor of Agrin

@article{Zhang2008LRP4SA,
  title={LRP4 Serves as a Coreceptor of Agrin},
  author={Bin Zhang and Shiwen Luo and Qiang Wang and Tatsuo Suzuki and Wen Cheng Xiong and Lin Mei},
  journal={Neuron},
  year={2008},
  volume={60},
  pages={285-297}
}
Neuromuscular junction (NMJ) formation requires agrin, a factor released from motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin. However, how signal is transduced from agrin to MuSK remains unclear. We report that LRP4, a low-density lipoprotein receptor (LDLR)-related protein, is expressed specifically in myotubes and binds to neuronal agrin. Its expression enables agrin binding and MuSK signaling in cells that otherwise do not respond to agrin. Suppression of… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 219 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 177 citations

220 Citations

0102030'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 220 citations based on the available data.

See our FAQ for additional information.