LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.

@article{Gajera2010LRP2IE,
  title={LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.},
  author={Chandresh R. Gajera and Helena Emich and Oleg Lioubinski and Annabel Christ and Ruth Beckervordersandforth-Bonk and Kazuaki Yoshikawa and Sebastian Bachmann and Erik Ils\o Christensen and Magdalena G{\"o}tz and Gerd Kempermann and Andrew S. Peterson and Thomas E. Willnow and Annette Hammes},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 11},
  pages={1922-30}
}
The microenvironment of growth factors in the subependymal zone (SEZ) of the adult brain provides the instructive milieu for neurogenesis to proceed in this germinal niche. In particular, tight regulation of bone morphogenetic protein (BMP) signaling is essential to balance proliferative and non-proliferative cell fate specification. However, the regulatory pathways that control BMP signaling in the SEZ are still poorly defined. We demonstrate that LRP2, a clearance receptor for BMP4 is… CONTINUE READING